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KMID : 0613820140240050485
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Journal of Life Science
2014 Volume.24 No. 5 p.485 ~ p.490
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Whitening Effect of Poria cocas Ethanol Extract by Inhibition of Melanin Synthesis
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Park Hye-Jung
Kwon Eun-Jeong
Kim Moon-Moo
Lee Kyung-Rok
Hong Il
Lee Do-Gyeong
Oh Yung-Hee
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Abstract
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Poria cocas has been reported to be effective in skin whitening. However, the direct effect of P. cocas ethanol extracts (PCEE) on melanin synthesis has not been scientifically studied. To elucidate the direct effect of PCEE on melanogenesis, a 3,4-dihydroxyindole-2-carboxylic acid (DOPA) synthesis assay, tyrosinase activity assay, and Western blotting for melanogenic proteins, including tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2 were performed in mouse B16F1 cells. The results revealed that PGEE inhibited melanin production in a dose-dependent manner by blocking the synthesis of DOPA. Although the activation of tyrosinase was not affected, the expression levels of TRP-1 and TRP-2 were controlled. These results suggest that PCEE has a whitening effect, indicating that it may be a useful agent in the development of whitening cosmetics.
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KEYWORD
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B16F1, DOPA, Melanin, Poria cocas, tyrosinase-related protein (TRP)-1, TRP-2
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